OpenAccessBelV2, OpenAccess, Analysis, bibRecord, 000041

TR-DB: An open-access database of compounds affecting the ethylene-induced triple response in Arabidopsis

Identifieur interne : 000041 ( OpenAccess/Analysis ); précédent : 000040; suivant : 000042

TR-DB: An open-access database of compounds affecting the ethylene-induced triple response in Arabidopsis

Auteurs : YUMING HU [Belgique] ; Pieter Callebert [Belgique] ; Ilse Vandemoortel [Belgique] ; LONG NGUYEN [Belgique] ; Dominique Audenaert [Belgique] ; Luc Verschraegen [Belgique] ; Filip Vandenbussche [Belgique] ; Dominique Van Der Straeten [Belgique]

Source :

Plant physiology and biochemistry : (Paris) [ 0981-9428 ] ; 2014.

RBID : Pascal:14-0104465

Descripteurs français

Pascal (Inist)
- Base de données, Réponse, Génétique, Phénotype, Libre accès, Arabidopsis thaliana, Ethylène, Cyclopropanecarboxylique acide(1-amino), Physiologie végétale.
Wicri :
- topic : Base de données, Génétique.

English descriptors

KwdEn :
- 1-Aminocyclopropanecarboxylic acid, Arabidopsis thaliana, Database, Ethylene, Genetics, Open access, Phenotype, Plant physiology, Response.

Abstract

Small molecules which act as hormone agonists or antagonists represent useful tools in fundamental research and are widely applied in agriculture to control hormone effects. High-throughput screening of large chemical compound libraries has yielded new findings in plant biology, with possible future applications in agriculture and horticulture. To further understand ethylene biosynthesis/signaling and its crosstalk with other hormones, we screened a 12,000 compound chemical library based on an ethylene-related bioassay of dark-grown Arabidopsis thaliana (L.) Heynh. seedlings. From the initial screening, 1313 (˜11%) biologically active small molecules altering the phenotype triggered by the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC), were identified. Selection and sorting in classes were based on the angle of curvature of the apical hook, the length and width of the hypocotyl and the root. A MySQL-database was constructed (https://chaos.ugent.be/WE15/) including basic chemical information on the compounds, images illustrating the phenotypes, phenotype descriptions and classification. The research perspectives for different classes of hit compounds will be evaluated, and some general screening tips for customized high-throughput screening and pitfalls will be discussed.

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream PascalFrancis, to step Checkpoint: 000002
to stream Main, to step Merge: 000275
to stream Main, to step Curation: 000275
to stream Main, to step Exploration: 000275
to stream OpenAccess, to step Extraction: 000041

Links to Exploration step

Pascal:14-0104465

Le document en format XML

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<front><div type="abstract" xml:lang="en">Small molecules which act as hormone agonists or antagonists represent useful tools in fundamental research and are widely applied in agriculture to control hormone effects. High-throughput screening of large chemical compound libraries has yielded new findings in plant biology, with possible future applications in agriculture and horticulture. To further understand ethylene biosynthesis/signaling and its crosstalk with other hormones, we screened a 12,000 compound chemical library based on an ethylene-related bioassay of dark-grown Arabidopsis thaliana (L.) Heynh. seedlings. From the initial screening, 1313 (˜11%) biologically active small molecules altering the phenotype triggered by the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC), were identified. Selection and sorting in classes were based on the angle of curvature of the apical hook, the length and width of the hypocotyl and the root. A MySQL-database was constructed (https://chaos.ugent.be/WE15/) including basic chemical information on the compounds, images illustrating the phenotypes, phenotype descriptions and classification. The research perspectives for different classes of hit compounds will be evaluated, and some general screening tips for customized high-throughput screening and pitfalls will be discussed.</div>
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TR-DB: An open-access database of compounds affecting the ethylene-induced triple response in Arabidopsis

TR-DB: An open-access database of compounds affecting the ethylene-induced triple response in Arabidopsis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri